School's executive director felt "the school needed a change in leadership."
Founding principal Heidi Campbell to step down at the end of the school year.
The school, which does not have a senior class yet, earns a B grade in state scoring.
Carla Major follows several other longtime members who left.
Schools for students with special circumstances do not perform well in state evaluations under current criteria.
A move into the former St. Rose de Lima site on Bayou Road is being discussed.
Of the seven A schools in the city, just one buses its students. That means some students fortunate enough to get into one of the best schools must take hours-long rides on public transportation, making them and their parents uneasy.
Board will hold a special meeting next week to consider extension for Keith Bartlett.
Board members knew they were going to take a vote but didn't put the item on the agenda.
Rising retirement costs may prompt school to withdraw from state system.